Research Papers

26. Modepalli V*, Fridrich A*, Agron M*, Moran Y (2018) The methyltransferase HEN1 is required in Nematostella vectensis for microRNA and piRNA stability as well as larval metamorphosis. PLOS Genet. 14: e1007590. *equal contribution. pubmed link

25. Dnyansagar R, Zimmermann B, Moran Y, Praher D, Sundberg P, Møller LF, Technau U (2018) Dispersal and speciation: The cross Atlantic relationship of two parasitic cnidarians. Mol. Phylogenet. Evol. 126: 346-355. pubmed link    

24. Columbus-Shenkar YY*, Sachkova MY*, Macrander J, Fridrich A, Modepalli V, Reitzel AM, Sunagar K, Moran Y (2018) Dynamics of venom composition across a complex life cycle. eLife 7: e35014. *equal contribution. pubmed link

23. Praher D, Zimmermann B, Genikhovich G, Columbus-Shenkar Y, Modepalli V, Aharoni R, Moran Y, Technau U (2017) Characterization of the piRNA pathway during development of the sea anemone Nematostella vectensis. RNA Biol. 14: 1727-1741. pubmed link

22. Modepalli V, Moran Y (2017) Evolution of miRNA Tailing by 3' Terminal Uridylyl Transferases in Metazoa. Genome Biol. Evol. 9: 1547-1560. pubmed link

21. Mauri M, Kirchner M, Aharoni R, Ciolli Mattioli C, van den Bruck D, Gutkovitch N, Modepalli V, Selbach M, Moran Y, Chekulaeva M (2017) Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution. Nucleic Acids Res. 45: 938-950 pubmed link

20. Sunagar K, Moran Y (2015) The Rise and Fall of an Evolutionary Innovation: Contrasting Strategies of Venom Evolution in Ancient and Young Animals. PLOS Genet. 11: e1005596. Link.

19. Jouiaei M*, Sunagar K*, Gross AF, Scheib H, Alewood PF, Moran Y#, Fry BG# (2015) Evolution of an ancient venom: recognition of a novel family of cnidarian toxins and the common evolutionary origin of sodium and potassium neurotoxins in sea anemone. Mol. Biol. Evol. 32:1598-610. *equal contribution; #co-corresponding authors. pubmed link

18. Moran Y, Zakon HH (2014) The evolution of the four subunits of voltage-gated calcium channels: ancient roots, increasing complexity and multiple losses. Genome Biol. Evol. 6: 2210-7. pubmed link

17. Gur Barzilai M, Kahn R, Regev N, Gordon D, Moran Y, Gurevitz M (2014) The specificity of Av3 sea anemone toxin for arthropods is determined at linker DI/SS2-S6 in the pore module of target sodium channels. Biochem. J. 463: 271-7. pubmed link

16. Moran Y, Fredman D, Praher D, Li XZ, Wee LM, Rentzsch F, Zamore PD, Technau U, Seitz H (2014) Cnidarian microRNAs frequently regulate targets by cleavage. Genome Res. 24: 651-63. pubmed link

15. Moran Y, Praher D, Fredman D, Technau U (2013) The evolution of microRNA pathway protein components in Cnidaria. Mol. Biol. Evol. 30: 2541-52. pubmed link

14. Orts DJ, Moran Y, Cologna CT, Peigneur S, Madio B, Praher D, Quinton L, De Pauw E, Bicudo JE, Tytgat J, de Freitas JC (2013) BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blockers. FEBS J.  280: 4839-52. pubmed link

13. Nesher N, Shapira E, Sher D, Moran Y, Tsveyer L, Turchetti-Maia AL, Horowitz M, Hochner B, Zlotkin E (2013) AdE-1, a new inotropic Na+ channel toxin from Aiptasia diaphana, is similar to, yet distinct from, known anemone Na+ channel toxins. Biochem. J. 451: 81-90. pubmed link

12.  Moran Y, Praher D, Schlesinger A, Ayalon A, Tal Y, Technau U (2013) Analysis of soluble protein contents from the nematocysts of a model sea anemone sheds light on venom evolution. Mar. Biotechnol. (NY). 15: 329-39. pubmed link

11. Gur Barzilai M, Reitzel AM, Kraus JEM, Gordon D, Technau U, Gurevitz M, Moran Y (2012) Convergent evolution of sodium ion selectivity in metazoan neuronal signaling. Cell Rep. 2: 242-248. pubmed link 

10. Moran Y*, Fredman D*, Szczesny P, Grynberg M, Technau U (2012) Recurrent horizontal transfer of bacterial toxin genes to eukaryotes. Mol. Biol. Evol. 29: 2223-2230. *equal contribution. pubmed link

9. Moran Y, Genikhovich G, Gordon D, Wienkoop S, Zenkert C, Özbek S, Technau U, Gurevitz M (2012) Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones. Proc. R. Soc. B 279: 1351-1358. pubmed link

8. Weinberger H*, Moran Y*,Gordon D, Turkov M, Kahn R, Gurevitz M (2010) Positions under positive selection – key for selectivity and potency of scorpion alpha-toxins. Mol. Biol. Evol. 27: 1025-34. *these authors contributed equally to this work. pubmed link

7. Moran Y, Weinberger H, Lazarus N, Gur M, Kahn R, Gordon D, Gurevitz M (2009) Fusion and retrotransposition events in the evolution of sea anemone neurotoxin genes. J. Mol. Evol. 69: 115-24. pubmed link

6. Cohen L*, Moran Y*, Sharon A, Segal D, Gordon D, Gurevitz M (2009) An innate immunity peptide of Drosophila melanogaster, interacts with the fly voltage-gated sodium channel. J. Biol. Chem. 284: 23558-63. *these authors contributed equally to this work. pubmed link

5. Moran Y, Weinberger H, Reitzel AM, Sullivan JC, Kahn R, Gordon D, Finnerty JR, Gurevitz, M (2008) Intron retention as a post-transcriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis. J. Mol. Biol. 380: 437-43. pubmed link

4. Moran Y, Weinberger H, Sullivan JC, Reitzel AM, Finnerty JR, Gurevitz M (2008) Concerted Evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome. Mol. Biol. Evol. 25: 737-47. pubmed link

3. Moran Y, Kahn R, Cohen L, Gur M, Karbat I, Gordon D, Gurevitz M (2007) Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na-channels. Biochem. J. 406: 41-48. pubmed link

2. Moran Y, Gurevitz M (2006) When positive selection of neurotoxin genes is missing: The riddle of the sea anemone Nematostella vectensis. FEBS J. 273: 3886-92. pubmed link

1. Moran Y, Cohen L, Kahn R, Karbat I, Gordon D, Gurevitz M (2006) Mutagenesis of the sea anemone toxin Av2 reveals key amino acid residues important for activity on insect voltage-gated sodium channels. Biochemistry 45: 8864-73. pubmed link




5. Moran Y, Agron M, Praher D, Technau U (2017) The evolutionary Origin of plant and animal microRNAs. Nat. Ecol. Evol. 1: 0027. link

4. Sunagar K, Morgenstern D, Reitzel AM, Moran Y (2015) Ecological venomics: How genomics, transcriptomics and proteomics can shed new light on the ecology and evolution of venom. J. Proteomics S1874-3919: 30131-7. pubmed link

3. Moran Y, Gur Barzilai M, Liebeskind BJ, Zakon HH (2015) Evolution of voltage-gated ion channels at the emergence of Metazoa. J. Exp. Biol. 218: 515-525. pubmed link


2. Qiu X, Brown, KV, Moran Y, Chen D (2010) Sirtuin regulation in calorie restriction. Biochim. Biophys. Acta, 1804: 1576-83. pubmed link


1. Moran Y, Gordon D, Gurevitz M (2009) Sea anemone toxins affecting voltage-gated sodium channels - molecular and evolutionary features. Toxicon, 54: 1089-1101. pubmed link



2. Columbus-Shenkar YY, Sachkova MY, Fridrich A, Modepalli V, Sunagar K, Moran Y (2017) Dynamics of venom composition across a complex life cycle. bioRxiv, 159889. link

1. Sunagar K, Columbus-Shenkar YY, Fridrich A, Gutkovitch N, Aharoni R, Moran Y (2017) Cell type-specific expression profiling sheds light on the development of a peculiar neuron, housing a complex organelle. bioRxiv, 158063. link


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